RISING INCIDENCE OF TYPE 1 DIABETES IN BELGRADE CHILDREN AGED 0-14 IN THE PERIOD FROM 1982 TO 2005
S. Sipetic, M.D., Ph.D¹, J. Maksimovic, M.D., Ph.D¹, H. Vlajinac, M.D., Ph.D¹, I. Ratkov M.D., MSc¹, S. Sajic, M.D., Ph.D², D. Zdravkovic, M.D., Ph.D3, T. Sipetic, Phar. B.,sp 4
¹ Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia ² Children's Hospital, University of Belgrade, 3 Mother and Child Institute, University of Belgrade, 4 Medicines and Medical Devices Agency of Serbia

Background. Type- 1 diabetes is an autoimmune disease in which both genetic and environmental factors play a role in the etiology Aim. The aim of this study was to analyze incidence of type-1 diabetes. Methods. A retrospective technique was used to register all newly diagnosed cases of type-1 diabetes in Belgrade (Serbia) children at the age of 0-14 years between 1982 and 2005. The incidence was adjusted directly by age using the world Segi population as the standard. A total of 702 cases was identified from the two sources: patients' records from two pediatric hospitals in Belgrade referent for the disease, and from the population based register. Results. The average annual age adjusted incidence rate of type-1 diabetes for Belgrade was 10.4/100,000 (95% confidence interval (95% CI) = 3.8-15.4). It was slightly higher in boys than in girls. The age-specific annual incidence rates (per 100,000) for the age groups 0-4, 5-9, and 10-14 were 5.5 (95% CI = 4.5-6.7), 11.9 (95% CI = 10.5-13.5) and 15.4 (95% CI = 13.8- 17.1), respectively. Over the 24 years incidence rates significantly increased by 8.5% for boys and 3.0% for girls. The highest increase of incidence rate was in the 5-9 age group. Discussion. The results obtained are in line with data from other studies showing that the incidence of type-1 diabetes has been increasing in almost all populations worldwide.

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