Difference in the ratio of high-molecular weight (HMW) to total adiponectin and HMW adiponectin in late post-menopausal women
S. Matsui1, T. Yasui2, A. Tani1, T. Kato1, K. Kunimi1, H. Uemura3, A. Kuwahara1, T. Matsuzaki1, and M. Irahara1

1Department of Obstetrics and Gynecology; 2Department of Reproductive Technology, 3Department of Preventive Medicine;
Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

Objective: High-molecular weight (HMW) isoform
level and HMW ratio have been shown to be better predictors
of insulin sensitivity and metabolic syndrome than total
adiponectin level.We examined the changes in circulating levels
of HMWadiponectin and ratios of HMWto total adiponectin
in women during the menopausal transition. Methods: We
conducted a cross-sectional study in 217 healthy women and
divided them into 4 stages: 58 women in pre-menopausal, 69
women in perimenopausal, 62 women in early post-menopausal
and 28 women in late post-menopausal phase. Serum levels
of total adiponectin and HMWadiponectin were measured
by an enzyme-linked immunosorbent assay. Results: In late
post-menopausal women, HMW adiponectin level was significantly
higher than that in peri-menopausal women and the
HMW to total adiponectin ratio was significantly lower than
that in early post-menopausal women. In peri-menopausal
women, HMW adiponectin level was significantly lower than
that in pre-menopausal women and HMWto total adiponectin
ratio was significantly lower than the ratios in pre-menopausal
and early post-menopausal women. Conclusion: The ratio of
HMWto total adiponectin is low in late post-menopausal women,
though both levels of total and HMW adiponectin were
high after menopause in our cross-sectional study.
(J. Endocrinol. Invest. 36: 982-985, 2013)
©2013, Editrice Kurtis

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