Maximal lipid oxidation during exercise: A target for individualizing endurance training in obesity and diabetes?
J.F. Brun1, D. Malatesta2, and A. Sartorio3,4
1INSERM U1046 “Physiologie et Médecine Exprimentale du Coeur et du Muscle”, Université Montpellier 1, Université Montpellier 2; CHRU Montpellier, Département de Physiologie Clinique; Equipe d’Exploration Métabolique (CERAMM) Hôpital Lapeyronie, Montpellier, France; 2Institute of Sport Sciences University of Lausanne (ISSUL), Department of Physiology, Faculty of Biology and Medicine, Lausanne, Switzerland; 3Istituto Auxologico Italiano, IRCCS, Laboratorio Sperimentale Ricerche Auxo-endocrinologiche; 4Divisione Malattie Metaboliche, Milan and Verbania, Italy

This review summarizes the rationale for personalized exercise training in obesity and diabetes, targeted at the level of maximal lipid oxidation as can be determined by exercise calorimetry. This measurement is reproducible and reflects muscles’ ability to oxidize lipids. Targeted training at this level is well tolerated, increases the ability to oxidize lipids during exercise and improves body composition, lipid and inflammatory status, and glycated hemoglobin, thus representing a possible future strategy for exercise prescription in patients suffering from obesity and diabetes. (J. Endocrinol. Invest. 35: 686-691, 2012) ©2012, Editrice Kurtis

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