The Relationship between CAG Repeat Length Polymorphism and Infertility Women in Southern Chinese Han Women
Da-yue Tong 1, Jie Deng 2, Hong-yu Sun 1, Li-xian Chen 1, Xin-yao Wu 1*
1 Department of Forensic Medicine, Zhongshan Medical College, Sun Yat-sen University, Guangzhou 510080, China 2 Reproductive Centers, the First Hospitals Affiliated to Sun Yat-sen University, Guangzhou 510080, China

Objective:To research the relationship between polymorphism of trinucleotide (CAG)n repeat alleles of the Exon 1 of androgen receptor gene and women with polycystic ovary syndrome (PCOS),or with endometriosis. Materials and Methods: The 141 control women and 74 women with PCOS and with endometriosis were recruited. The (CAG)n repeat alleles were genotyped with 3100 genetic analyser. The repeat number and frequency distributions of (CAG)n alleles were compared and analyed statistically. Results:The results showed that mean repeat number of the (CAG)n in women with PCOS was significantly lower than that in controls (P < 0.001). The mean repeat number was significantly difference between infertile women with endometriosis(p<0.05). However, the between infertile women with PCOS and the fertility women with PCOS was not significant (P > 0.05). Conclusions: These data indicated that (CAG)n repeat polymorphism have some influence, but have not a straight relationship in infertility women with PCOS and with endometriosis in this research population.

DOI: 10.3275/6871 pubblicato: 24.02.2010 [« Indietro]  [Manoscritto accettato]