Vitamin D deficiency and myocardial structure and function in older men and women: The Hoorn Study
S. Pilz1, R.M.A. Henry2,3, M.B. Snijder2,4, R.M. van Dam5, G. Nijpels2,6, C.D.A. Stehouwer3, O. Kamp7, A. Tomaschitz1, T.R. Pieber1, J.M. Dekker2,8
1Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University of Graz, Austria 2EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands  3Department of Internal Medicine and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands 4Department of Health Sciences, Faculty of Earth and Life Sciences, VU University Amsterdam, The Netherlands 5Department of Nutrition, Harvard School of Public Health; Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA, USA 6Department of General Practice, VU University Medical Center, Amsterdam, The Netherlands 7Department of Physiology and Cardiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands 8Department of Epidemiology and Biostatistics and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands

Background: Vitamin D deficiency is frequently observed in heart failure patients and it has been shown that Vitamin D exerts various effects on the heart that may be relevant for the pathogenesis of myocardial diseases. Aims: We aimed to elucidate the largely unknown association of 25-hydroxyvitamin D (25[OH]D) serum levels with echocardiographic measures of left ventricular (LV) structure and function. Material/Subjects and Methods: We measured 25(OH)D serum levels and performed standardized LV echocardiograms in 614 persons from a population based cohort of older men and women. Echocardiographic data were used to calculate LV mass and LV geometry and for classification of systolic and diastolic dysfunction. To consider the seasonal variations of 25(OH)D levels we categorized our study participants according to season specific 25(OH)D quartiles. Results: LV systolic function, LV mass and LV geometry were not significantly associated with 25(OH)D serum levels. In binary logistic regression analyses, the prevalence of LV diastolic dysfunction was significantly higher in the first season specific 25(OH)D quartile when compared to the fourth quartile (odds ratio 2.32 [95% CI: 1.42-3.80]; p=0.001) but significance was lost after adjustments for age (odds ratio 1.51 [0.89-2.57]; p=0.123 ) and established risk factors for heart failure (odds ratio 1.47 [0.84-2.59]; p=0.178). Conclusions: Serum levels of 25(OH)D are not significantly associated with LV structure and function but a non-significant trend towards increased risk of diastolic dysfunction in persons with vitamin D deficiency warrants further studies.

DOI: 10.3275/6883 pubblicato: 05.03.2010 [« Indietro]  [Manoscritto accettato]