Serum levels of the adipokine lipocalin-2 are increased in preeclampsia
Holger Stepan1, Anne Philipp2, Matthias Reiche2, Katrin Klostermann1, Susanne Schrey1, Constanze Reisenbüchler1, Ulrike Lossner2, Jürgen Kratzsch3, Matthias Bluher2, Michael Stumvoll2, and Mathias Fasshauer2
1: University of Leipzig, Department of Obstetrics, 04103 Leipzig, Germany 2: University of Leipzig, Department of Internal Medicine III, 04103 Leipzig, Germany 3: University of Leipzig, Institute of Laboratory Medicine, 04103 Leipzig, Germany

Background: Preeclampsia (PE) is a serious complication in pregnancy which increases the future risk for vascular and metabolic disease in both mother and newborn. Recently, lipocalin-2 has been introduced as a novel adipokine which contributes to obesity, insulin resistance, and vascular disease. Aim: In the current study, we investigated lipocalin-2 serum levels in PE patients as compared to healthy gestational age-matched controls. Subjects and Methods: Lipocalin-2 serum concentrations were quantified by ELISA in control (n=22) and PE (n=22) patients. Furthermore, lipocalin-2 levels were correlated to clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation. Results: Median maternal lipocalin-2 concentrations were significantly increased in PE (121.3 μ/l) as compared to control subjects (99.8 μ/l) (p < 0.05). Furthermore, circulating lipocalin-2 correlated positively with diastolic blood pressure, creatinine, and C reactive protein. In multivariate analyses, creatinine and C reactive protein remained independently associated with lipocalin-2 levels. Conclusions: We demonstrate that maternal lipocalin-2 concentrations are significantly increased in PE. Furthermore, markers of renal function and inflammation independently predict circulating lipocalin-2.

DOI: 10.3275/6884 pubblicato: 05.03.2010 [« Indietro]  [Manoscritto accettato]