Relationships between serum adiponectin, apelin, leptin, resistin, visfatin levels and bone mineral density, and bone biochemical markers in postmenopausal Chinese women
Hong Zhang, Hui Xie, Qin Zhao, Er-Yuan Liao, Gen-Qing Xie, Xian-Ping Wu,and Xiang-Hang Luo*
Institute of Endocrinology & Metabolism, The Second Xiangya Hospital of Central South University, 86# Middle Renmin Road, Changsha, Hunan 410011, PR China

Background: Adiponectin, apelin, leptin, resistin, and visfatin, as the main circulating peptides secreted by adipose tissue, are potential contributors to bone metabolism. However, their association with bone mineral density (BMD) is unclear. Aim:The present study investigated whether these serum adipocytokines levels are associated with BMD and bone turnover markers. Methods: Serum adiponectin, apelin, leptin, resistin, visfatin levels, bone turnover biochemical markers, and BMD were determined in 336 postmenopausal Chinese women (41-81 years old). Results: Adiponectin was negatively correlated with fat mass, while leptin had a positively correlation. In the multiple linear stepwise regression analysis, year since menopause, lean mass, estradiol, and adiponectin, but not fat mass, apelin, leptin, resistin and visfatin, were independent predictors of BMD. The significant positive correlations between adiponectin and bone-specific alkaline phosphatase (BAP), bone cross-linked N-telopeptides of type I collagen (NTX) were found. Conclusions: Adiponectin was an independent predictor of BMD in postmenopausal Chinese women, and positively correlated with bone turnover biochemical markers. It suggested that adiponectin may exert a negative effect on bone mass by promoting excessive bone resorption associated with bone loss in postmenopausal women.

DOI: 10.3275/6886 pubblicato: 05.03.2010 [« Indietro]  [Manoscritto accettato]